In pharmacology, the term mechanism of action (MOA) refers to the specific biochemical interaction through which a drug substance produces its pharmacological effect. Usually a new pharmaceutical substance is designed in such a way that it is capable of initiating on a well-known biochemical reaction in the organism. Read more...
Extremely low concentrations of SkQ1 have shown pharmacological effect in our experiments. Such low-dose effect of SkQ1 can be attributed to two important properties of the compound:
Human eyes may develop various serious pathologies, especially with age. Many of those pathologies have been connected to oxidative stress involving mitochondria. Due to highly targeted delivery of SkQ1 to mitochondria and its potency as antioxidant, topical application of SkQ1-based formulations proved to be very effective in treating several eye pathologies in animal models and in humans. Read more...
Inflammation is the body’s first line of defense against invading microbes, and it also plays an important role in eliminating diseased cells and damaged tissue in wounds and bruises. However, as we get older, inflammation turns against the body. Inflammation in cartilage is the proximate cause of arthritis, and in our arteries, inflammation creates the plaques which can lead to heart attacks and strokes. Read more...
The human brain is responsible for approximately 20% of our body oxygen consumption, therefore exposing itself to high levels of ROS. Many recent studies provided strong experimental evidence of involvement of oxidative stress in pathogenesis of age-related neurological disorders. Read more...